FAM173B antibody (AA 1-233)

Catalog No. ABIN6140451

The Rabbit Polyclonal anti-FAM173B antibody has been validated for WB. It is suitable to detect FAM173B in samples from Human.

Quick Overview for FAM173B antibody (AA 1-233) (ABIN6140451)

Target: FAM173B (Family with Sequence Similarity 173, Member B (FAM173B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM173B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FAM173B Antibody

Binding Specificity: AA 1-233

Sequence: MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA VYAVATPFVT PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG RIVIAAAKKG FTAVGYELNP WLVWYSRYRA WREGVHGSAK FYISDLWKVT FSQYSNVVIF GVPQMMLQLE KKLERELEDD ARVIACRFPF PHWTPDHVTG EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human FAM173B (NP_954584.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FAM173B

Target: FAM173B (Family with Sequence Similarity 173, Member B (FAM173B))

Alternative Name: FAM173B

Background: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS and on the engagement of spinal cord microglia.,FAM173B,JS-2,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,FAM173B

Molecular Weight: 24 kDa/26 kDa

Gene ID: 134145

UniProt: Q6P4H8