FTO antibody (AA 416-505)

Catalog No. ABIN6140795

This Rabbit Polyclonal antibody specifically detects FTO in WB and IP. It exhibits reactivity toward Human.

Quick Overview for FTO antibody (AA 416-505) (ABIN6140795)

Target: FTO (Fat Mass and Obesity-Associated (FTO))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FTO antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-FTO Antibody

Binding Specificity: AA 416-505

Sequence: AVLHEVKREG LPVEQRNEIL TAILASLTAR QNLRREWHAR CQSRIARTLP ADQKPECRPY WEKDDASMPL PFDLTDIVSE LRGQLLEAKP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-505 of human FTO (NP_001073901.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FTO

Target: FTO (Fat Mass and Obesity-Associated (FTO))

Alternative Name: FTO

Background: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.,FTO,ALKBH9,BMIQ14,GDFD,Epigenetics & Nuclear Signaling,Cancer,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Neuroscience,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,FTO

Molecular Weight: 6 kDa/12 kDa/14 kDa/58 kDa

Gene ID: 79068

UniProt: Q9C0B1