GNA12 antibody (AA 1-200)

Catalog No. ABIN6141192

This Rabbit Polyclonal antibody specifically detects GNA12 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for GNA12 antibody (AA 1-200) (ABIN6141192)

Target: GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNA12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GNA12 Antibody

Binding Specificity: AA 1-200

Sequence: MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK YFLDNLDRIG QLNYFPSKQD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GNA12 (NP_031379.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GNA12

Target: GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))

Alternative Name: GNA12

Background: Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.,GNA12,NNX3,RMP,gep,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,mTOR Signaling Pathway,MAPK-JNK Signaling Pathway,GNA12

Molecular Weight: 34 kDa/37 kDa/44 kDa

Gene ID: 2768

UniProt: Q03113