KCNQ2 antibody (AA 254-393)

Catalog No. ABIN6142772

Product Details anti-KCNQ2 Antibody

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Binding Specificity: AA 254-393

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EKGENDHFDT YADALWWGLI TLTTIGYGDK YPQTWNGRLL AATFTLIGVS FFALPAGILG SGFALKVQEQ HRQKHFEKRR NPAAGLIQSA WRFYATNLSR TDLHSTWQYY ERTVTVPMYR YRRRAPATKQ LFHFLFSICS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 254-393 of human KCNQ2 (NP_742107.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KCNQ2

Target: KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))

Alternative Name: KCNQ2 (KCNQ2 Products)

Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.,KCNQ2,BFNC,EBN,EBN1,ENB1,HNSPC,KCNA11,KV7.2,Neuroscience,Neurodegenerative Diseases,KCNQ2

Molecular Weight: 44 kDa/92 kDa/93 kDa/94 kDa/95 kDa

Gene ID: 3785

UniProt: O43526