MANF antibody (AA 25-182)

Catalog No. ABIN6143461

This Rabbit Polyclonal antibody specifically detects MANF in WB, IHC, IP and IF. It exhibits reactivity toward Human.

Quick Overview for MANF antibody (AA 25-182) (ABIN6143461)

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MANF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-MANF Antibody

Binding Specificity: AA 25-182

Sequence: SRALRPGDCE VCISYLGRFY QDLKDRDVTF SPATIENELI KFCREARGKE NRLCYYIGAT DDAATKIINE VSKPLAHHIP VEKICEKLKK KDSQICELKY DKQIDLSTVD LKKLRVKELK KILDDWGETC KGCAEKSDYI RKINELMPKY APKAASAR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF (NP_006001.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100,IP,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MANF

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Alternative Name: MANF

Background: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.,MANF,ARMET,ARP,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Growth factor,Neuroscience,MANF

Molecular Weight: 20 kDa

Gene ID: 7873

UniProt: P55145