MCM10 antibody (AA 616-875)

Catalog No. ABIN6143639

This Rabbit Polyclonal antibody specifically detects MCM10 in WB. It exhibits reactivity toward Human.

Quick Overview for MCM10 antibody (AA 616-875) (ABIN6143639)

Target: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MCM10 Antibody

Binding Specificity: AA 616-875

Sequence: RLEGAPATMT PKLGRGVLEG DDVLFYDESP PPRPKLSALA EAKKLAAITK LRAKGQVLTK TNPNSIKKKQ KDPQDILEVK ERVEKNTMFS SQAEDELEPA RKKRREQLAY LESEEFQKIL KAKSKHTGIL KEAEAEMQER YFEPLVKKEQ MEEKMRNIRE VKCRVVTCKT CAYTHFKLLE TCVSEQHEYH WHDGVKRFFK CPCGNRSISL DRLPNKHCSN CGLYKWERDG MLKEKTGPKI GGETLLPRGE EHAKFLNSLK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MCM10

Target: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Alternative Name: MCM10

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.,MCM10,CNA43,DNA43,PRO2249,Epigenetics & Nuclear Signaling,MCM10

Molecular Weight: 98 kDa

Gene ID: 55388

UniProt: Q7L590

Pathways: Mitotic G1-G1/S Phases, DNA Replication