MEPCE antibody (AA 470-689)

Catalog No. ABIN6143737

This anti-MEPCE antibody is a Rabbit Polyclonal antibody detecting MEPCE in IF. Suitable for Human.

Quick Overview for MEPCE antibody (AA 470-689) (ABIN6143737)

Target: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEPCE antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-MEPCE Antibody

Binding Specificity: AA 470-689

Sequence: MVGLDIDSRL IHSARQNIRH YLSEELRLPP QTLEGDPGAE GEEGTTTVRK RSCFPASLTA SRGPIAAPQV PLDGADTSVF PNNVVFVTGN YVLDRDDLVE AQTPEYDVVL CLSLTKWVHL NWGDEGLKRM FRRIYRHLRP GGILVLEPQP WSSYGKRKTL TETIYKNYYR IQLKPEQFSS YLTSPDVGFS SYELVATPHN TSKGFQRPVY LFHKARSPSH

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2).

Isotype: IgG

Application Details

Application Notes: IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MEPCE

Target: MEPCE (Methylphosphate Capping Enzyme (MEPCE))

Alternative Name: MEPCE

Background: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA, leading to stabilize it. Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC. In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex. MEPCE has a non-enzymatic function in the 7SK RNP complex, interaction with LARP7 within the 7SK RNP complex occluding its catalytic center.,MEPCE,BCDIN3,Epigenetics & Nuclear Signaling,RNA Binding,MEPCE

Molecular Weight: 24 kDa/74 kDa

Gene ID: 56257

UniProt: Q7L2J0

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection