METAP2 antibody (AA 1-220)

Catalog No. ABIN6143752

This Rabbit Polyclonal antibody specifically detects METAP2 in WB. It exhibits reactivity toward Human.

Quick Overview for METAP2 antibody (AA 1-220) (ABIN6143752)

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METAP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-METAP2 Antibody

Binding Specificity: AA 1-220

Sequence: MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human METAP2 (NP_006829.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for METAP2

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Alternative Name: METAP2

Background: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.,METAP2,MAP2,MNPEP,p67eIF2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,METAP2

Molecular Weight: 50 kDa/52 kDa

Gene ID: 10988

UniProt: P50579

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling