METTL3 antibody (AA 1-156)

Catalog No. ABIN6143771

The Rabbit Polyclonal anti-METTL3 antibody has been validated for WB, IHC, IF and IP. It is suitable to detect METTL3 in samples from Human. There are 2+ publications available.

Quick Overview for METTL3 antibody (AA 1-156) (ABIN6143771)

Target: METTL3 (Methyltransferase Like 3 (METTL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-METTL3 Antibody

Binding Specificity: AA 1-156

Sequence: MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-156 of human METTL3 (NP_062826.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:20 - 1:50

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-METTL3 antibody (ABIN6143771)

Xiang, Yang, Liu, Wu, Chen, Yang: "N6-Methyladenosines Modulate A-to-I RNA Editing." in: Molecular cell, Vol. 69, Issue 1, pp. 126-135.e6, (2018) (PubMed).

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Target Details for METTL3

Target: METTL3 (Methyltransferase Like 3 (METTL3))

Alternative Name: METTL3

Background: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.,IME4,M6A,MT-A70,Spo8,hMETTL3,METTL3,Epigenetics & Nuclear Signaling,METTL3

Molecular Weight: 25 kDa/64 kDa

Gene ID: 56339

UniProt: Q86U44