MS4A2 antibody (AA 1-100)

Catalog No. ABIN6144054

The Rabbit Polyclonal anti-MS4A2 antibody has been validated for WB. It is suitable to detect MS4A2 in samples from Human.

Quick Overview for MS4A2 antibody (AA 1-100) (ABIN6144054)

Target: MS4A2 (Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment of IgE, High Affinity I, Receptor For, beta Polypeptide) (MS4A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MS4A2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MS4A2 Antibody

Binding Specificity: AA 1-100

Sequence: MDTESNRRAN LALPQEPSSV PAFEVLEISP QEVSSGRLLK SASSPPLHTW LTVLKKEQEF LGVTQILTAM ICLCFGTVVC SVLDISHIEG DIFSSFKAGY

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MS4A2

Target: MS4A2 (Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment of IgE, High Affinity I, Receptor For, beta Polypeptide) (MS4A2))

Alternative Name: MS4A2

Background: The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.,MS4A2,APY,ATOPY,FCER1B,FCERI,IGEL,IGER,IGHER,MS4A1,Immunology & Inflammation,MS4A2

Molecular Weight: 26 kDa

Gene ID: 2206

UniProt: Q01362

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process