MS4A2 antibody (AA 1-59)

Catalog No. ABIN7155184

Product Details anti-MS4A2 Antibody

Target: MS4A2 (Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment of IgE, High Affinity I, Receptor For, beta Polypeptide) (MS4A2))

Binding Specificity: AA 1-59

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MS4A2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human High affinity immunoglobulin epsilon receptor subunit beta protein (1-59AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MS4A2

Target: MS4A2 (Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment of IgE, High Affinity I, Receptor For, beta Polypeptide) (MS4A2))

Alternative Name: MS4A2 (MS4A2 Products)

Synonyms: APY antibody, ATOPY antibody, FCER1B antibody, FCERI antibody, IGEL antibody, IGER antibody, IGHER antibody, MS4A1 antibody, FcRB antibody, Fce1b antibody, Fcer1b antibody, Fcrbeta antibody, Ms4a1 antibody, fcERI antibody, FCIGA antibody, membrane spanning 4-domains A2 antibody, membrane-spanning 4-domains, subfamily A, member 2 antibody, MS4A2 antibody, Ms4a2 antibody

Background:

Background: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

Aliases: APY antibody, ATOPY antibody, Fc epsilon receptor I beta-chain antibody, Fc IgE receptor beta chain antibody, FCER1B antibody, FCERB_HUMAN antibody, FcERI antibody, High affinity immunoglobulin epsilon receptor subunit beta antibody, IgE Fc receptor subunit beta antibody, IGEL antibody, IGHER antibody, Membrane-spanning 4-domains subfamily A member 2 antibody, MS4A1 antibody, Ms4a2 antibody

UniProt: Q01362

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process