MSH3 antibody (AA 617-761)

Catalog No. ABIN6144059

The Rabbit Polyclonal anti-MSH3 antibody has been validated for WB. It is suitable to detect MSH3 in samples from Human.

Quick Overview for MSH3 antibody (AA 617-761) (ABIN6144059)

Target: MSH3 (MutS Homolog 3 (MSH3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MSH3 Antibody

Binding Specificity: AA 617-761

Sequence: FNTSEEHHAD MYRSDLPNPD TLSAELHCWR IKWKHRGKDI ELPSTIYEAL HLPDIKFFPN VYALLKVLCI LPVMKVENER YENGRKRLKA YLRNTLTDQR SSNLALLNIN FDIKHDLDLM VDTYIKLYTS KSELPTDNSE TVENT

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Alternative Name: MSH3

Background: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.,MSH3,DUP,FAP4,MRP1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,MSH3

Molecular Weight: 127 kDa

Gene ID: 4437

UniProt: P20585

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response