MTF2 antibody (AA 1-190)

Catalog No. ABIN6144136

This anti-MTF2 antibody is a Rabbit Polyclonal antibody detecting MTF2 in WB. Suitable for Human.

Quick Overview for MTF2 antibody (AA 1-190) (ABIN6144136)

Target: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTF2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MTF2 Antibody

Binding Specificity: AA 1-190

Sequence: MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MTF2 (NP_001157864.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MTF2

Target: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Alternative Name: MTF2

Background: Polycomb group (PcG protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity. Binds to the metal-regulating-element (MRE of MT1A gene promoter (By similarity.,MTF2,M96,PCL2,TDRD19A,dJ976O13.2,Epigenetics & Nuclear Signaling,Transcription Factors,Chromatin Remodeling,MTF2

Molecular Weight: 29 kDa/55 kDa/60 kDa/67 kDa

Gene ID: 22823

UniProt: Q9Y483

Pathways: Stem Cell Maintenance