PDE1A antibody (AA 446-545)

Catalog No. ABIN6145346

This anti-PDE1A antibody is a Rabbit Polyclonal antibody detecting PDE1A in WB. Suitable for Human.

Quick Overview for PDE1A antibody (AA 446-545) (ABIN6145346)

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE1A Antibody

Binding Specificity: AA 446-545

Sequence: EASKAETSSY VASSSTTIVG LHIADALRRS NTKGSMSDGS YSPDYSLAAV DLKSFKNNLV DIIQQNKERW KELAAQGESD LHKNSEDLVN AEEKHDETHS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 446-545 of human PDE1A (NP_005010.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE1A

Target: PDE1A (Phosphodiesterase 1A (PDE1A))

Alternative Name: PDE1A

Background: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1, MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109], Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009],PDE1A,CAM-PDE-1A,HCAM-1,HCAM1,HSPDE1A,PDE1A

Molecular Weight: 57 kDa/58 kDa/59 kDa/60 kDa/61 kDa/62 kDa/63 kDa

Gene ID: 5136

UniProt: P54750

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma