PHF19 antibody (AA 1-207)

Catalog No. ABIN6145539

This anti-PHF19 antibody is a Rabbit Polyclonal antibody detecting PHF19 in WB and IF. Suitable for Human.

Quick Overview for PHF19 antibody (AA 1-207) (ABIN6145539)

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHF19 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PHF19 Antibody

Binding Specificity: AA 1-207

Sequence: MENRALDPGT RDSYGATSHL PNKGALAKVK NNFKDLMSKL TEGQYVLCRW TDGLYYLGKI KRVSSSKQSC LVTFEDNSKY WVLWKDIQHA GVPGEEPKCN ICLGKTSGPL NEILICGKCG LGYHQQCHIP IAGSADQPLL TPWFCRRCIF ALAVRVSLPS SPVPASPASS SGADQRLPSQ SLSSKQKGHT WALETDSASA TVLGQDL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human PHF19 (NP_001009936.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PHF19

Target: PHF19 (PHD Finger Protein 19 (PHF19))

Alternative Name: PHF19

Background: Polycomb group (PcG protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.,PHF19,MTF2L1,PCL3,TDRD19B,Epigenetics & Nuclear Signaling,Transcription Factors,PHF19

Molecular Weight: 14 kDa/22 kDa/65 kDa

Gene ID: 26147

UniProt: Q5T6S3

Pathways: Stem Cell Maintenance