PRDM6 antibody (AA 376-595)

Catalog No. ABIN6146147

This Rabbit Polyclonal antibody specifically detects PRDM6 in WB. It exhibits reactivity toward Human.

Quick Overview for PRDM6 antibody (AA 376-595) (ABIN6146147)

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRDM6 Antibody

Binding Specificity: AA 376-595

Sequence: LQCIAQDENL NVPSTVMEAM CRQDALQPFN KSSKLAPTTQ QRSVVFPQTP CSRNFSLLDK SGPIESGFNQ INVKNQRVLA SPTSTSQLHS EFSDWHLWKC GQCFKTFTQR ILLQMHVCTQ NPDRPYQCGH CSQSFSQPSE LRNHVVTHSS DRPFKCGYCG RAFAGATTLN NHIRTHTGEK PFKCERCERS FTQATQLSRH QRMPNECKPI TESPESIEVD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-595 of human PRDM6 (NP_001129711.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Alternative Name: PRDM6

Background: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.,PRDM6,KMT8C,PDA3,PRISM,Epigenetics & Nuclear Signaling,PRDM6

Molecular Weight: 14 kDa/46 kDa/64 kDa

Gene ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation