RIC8A antibody (AA 362-531)

Catalog No. ABIN6146947

The Rabbit Polyclonal anti-RIC8A antibody has been validated for WB. It is suitable to detect RIC8A in samples from Human.

Quick Overview for RIC8A antibody (AA 362-531) (ABIN6146947)

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIC8A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RIC8A Antibody

Binding Specificity: AA 362-531

Sequence: DVRTRPEVGE MLRNKLVRLM THLDTDVKRV AAEFLFVLCS ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTDEYKEAKA SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVTMFDKLS RNRVIQPMGM SPRGHLTSLQ DAMCETMEQQ LSSDPDSDPD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 362-531 of human RIC8A (NP_001273063.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RIC8A

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Alternative Name: RIC8A

Background: Guanine nucleotide exchange factor (GEF, which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i-alpha protein, possibly leading to release G(i-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i-alpha-GDP complex (By similarity. Also acts as an activator for G(q-alpha (GNAQ protein by enhancing the G(q-coupled receptor-mediated ERK activation.,RIC8A,RIC8,Signal Transduction,G protein signaling,RIC8A

Molecular Weight: 58 kDa/59 kDa/60 kDa

Gene ID: 60626

UniProt: Q9NPQ8

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Asymmetric Protein Localization