Ribonuclease H1 antibody (AA 1-286)

Catalog No. ABIN6146988

This anti-Ribonuclease H1 antibody is a Rabbit Polyclonal antibody detecting Ribonuclease H1 in WB and IHC. Suitable for Human.

Quick Overview for Ribonuclease H1 antibody (AA 1-286) (ABIN6146988)

Target: Ribonuclease H1 (RNASEH1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ribonuclease H1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Ribonuclease H1 Antibody

Binding Specificity: AA 1-286

Sequence: MSWLLFLAHR VALAALPCRR GSRGFGMFYA VRRGRKTGVF LTWNECRAQV DRFPAARFKK FATEDEAWAF VRKSASPEVS EGHENQHGQE SEAKASKRLR EPLDGDGHES AEPYAKHMKP SVEPAPPVSR DTFSYMGDFV VVYTDGCCSS NGRRRPRAGI GVYWGPGHPL NVGIRLPGRQ TNQRAEIHAA CKAIEQAKTQ NINKLVLYTD SMFTINGITN WVQGWKKNGW KTSAGKEVIN KEDFVALERL TQGMDIQWMH VPGHSGFIGN EEADRLAREG AKQSED

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human RNASEH1 (NP_002927.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Ribonuclease H1

Target: Ribonuclease H1 (RNASEH1)

Alternative Name: RNASEH1

Background: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes, two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2.,RNASEH1,H1RNA,PEOB2,RNH1,Epigenetics & Nuclear Signaling,RNASEH1

Molecular Weight: 32 kDa

Gene ID: 246243

UniProt: O60930