CD81 antibody
Quick Overview for CD81 antibody (ABIN614802)
Target
See all CD81 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Specificity
- This antibody reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
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Cross-Reactivity (Details)
- Species reactivity (tested):Human, Feline (Cat), Rabbit
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Purification
- Protein-A affinity chromatography
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Purity
- > 95 % pure by SDS-PAGE
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Immunogen
- MOLT-4 (human T-ALL cell line)
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Isotype
- IgG1
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Preservative
- Sodium azide
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Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes." in: The Journal of biological chemistry, Vol. 273, Issue 32, pp. 20121-7, (1998) (PubMed).
: "
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Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes." in: The Journal of biological chemistry, Vol. 273, Issue 32, pp. 20121-7, (1998) (PubMed).
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- CD81
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Alternative Name
- CD81 / TAPA1
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Background
- CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.Synonyms: 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1
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Gene ID
- 975
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NCBI Accession
- NP_004347
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UniProt
- P60033
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Pathways
- Inositol Metabolic Process, Hepatitis C
Target
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