SPAG8 antibody (AA 220-420)

Catalog No. ABIN6148323

The Rabbit Polyclonal anti-SPAG8 antibody has been validated for WB and IHC. It is suitable to detect SPAG8 in samples from Human.

Quick Overview for SPAG8 antibody (AA 220-420) (ABIN6148323)

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SPAG8 Antibody

Binding Specificity: AA 220-420

Sequence: LVADRVPNYT SWSQHCPWEP QKQPPWEFLQ VLEPGARGLW KPPDIKGKLM VCYETLPRGQ CLLYNWEEER ATNHLDQVPS MQDGSESFFF RHGHRGLLTM QLKSPMPSST TQKDSYQPPG NVYWPLRGKR EAMLEMLLQH QICKEVQAEQ EPTRKLFEVE SVTHHDYRME LAQAGTPAPT KPHDYRQEQP ETFWIQRAPQ L

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human SPAG8 (NP_758516.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPAG8

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Alternative Name: SPAG8

Background: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.,SPAG8,BS-84,CILD28,CT142,HSD-1,SMP1,SPAG3,hSMP-1,Cell Biology & Developmental Biology,Cell Cycle,Cell differentiation,Stem Cells,Germline Stem Cells,SPAG8

Molecular Weight: 44 kDa/51 kDa/53 kDa

Gene ID: 26206

UniProt: Q99932