APOC1 antibody

Catalog No. ABIN614885

The Goat Polyclonal anti-APOC1 antibody is suitable to detect APOC1 in samples from Human. It has been validated for WB, EIA and IHC (p).

Quick Overview for APOC1 antibody (ABIN614885)

Target: APOC1 (Apolipoprotein C-I (APOC1))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This APOC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APOC1 Antibody

Specificity: This antibody recognizes human Apo C-I in plasma and lipoproteins. Does not cross-react with plasma Apo A-I, Apo A-II, Apo B-100, Apo C-II, Apo C-III and Apo-E.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogen: Native human Apo C-I Genename: APOC1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2, 0.5 mM EDTA, 0.02 % sodium azide, 40 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for APOC1

Target: APOC1 (Apolipoprotein C-I (APOC1))

Alternative Name: Apolipoprotein C I (Apo CI)

Background: Apolipoprotein (apo) C-I gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A copy of the apo C-I gene, apo C-I', is located 4 kb downstream in the same orientation, on the same chromosome. However, apo C-I' gene has no detectable mRNA product in any tissue, suggesting that it may be a pseudogene. The ap °C-I gene is 4653 bases long and the apo C-I' is 4387 base pairs, and each contains four exons and 3 introns. The differences between the two genes includes a change of the codon for Gln-2 of the signal peptide region of apo C-I', which introduces a translation stop signal. A major difference between the two sequences is also found in the second and third introns of the ap °C-I' gene, which contains 7.5 instead of 9 copies of Alu family sequences.Synonyms: Apo-CI, Ap °C-I, Ap °C1, Apolipoprotein C-I, Apolipoprotein C1

Gene ID: 341

NCBI Accession: NP_001636

UniProt: P02654

Pathways: Apoptosis