TET2 antibody (AA 1833-2002)

Catalog No. ABIN6149017

The Rabbit Polyclonal anti-TET2 antibody has been validated for WB, IHC and IF. It is suitable to detect TET2 in samples from Human. There is 1 publication available.

Quick Overview for TET2 antibody (AA 1833-2002) (ABIN6149017)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TET2 Antibody

Binding Specificity: AA 1833-2002

Sequence: VQGVASGAED NDEVWSDSEQ SFLDPDIGGV AVAPTHGSIL IECAKRELHA TTPLKNPNRN HPTRISLVFY QHKSMNEPKH GLALWEAKMA EKAREKEEEC EKYGPDYVPQ KSHGKKVKRE PAEPHETSEP TYLRFIKSLA ERTMSVTTDS TVTTSPYAFT RVTGPYNRYI

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1833-2002 of human TET2 (NP_001120680.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TET2 antibody (ABIN6149017)

Yu, Liu, Liu, Wang, Liu, Miao, Du, Yang: "Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 6132, (2018) (PubMed).

Target Details for TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Alternative Name: TET2

Background: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.,MDS,KIAA1546,TET2,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,DNA Demethylation,TET2

Molecular Weight: 130 kDa/133 kDa/223 kDa

Gene ID: 54790

UniProt: Q6N021

Pathways: Warburg Effect