TGS1 antibody (AA 714-853)

Catalog No. ABIN6149101

The Rabbit Polyclonal anti-TGS1 antibody is suitable to detect TGS1 in samples from Human. It has been validated for WB.

Quick Overview for TGS1 antibody (AA 714-853) (ABIN6149101)

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TGS1 Antibody

Binding Specificity: AA 714-853

Sequence: RVIAIDIDPV KIALARNNAE VYGIADKIEF ICGDFLLLAS FLKADVVFLS PPWGGPDYAT AETFDIRTMM SPDGFEIFRL SKKITNNIVY FLPRNADIDQ VASLAGPGGQ VEIEQNFLNN KLKTITAYFG DLIRRPASET

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 714-853 of human TGS1 (NP_079107.6).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TGS1

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Alternative Name: TGS1

Background: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7G caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7G cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs. Plays a role in transcriptional regulation.,TGS1,NCOA6IP,PIMT,PIPMT,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,TGS1

Molecular Weight: 96 kDa

Gene ID: 96764

UniProt: Q96RS0

Pathways: Mitotic G1-G1/S Phases, Regulation of Lipid Metabolism by PPARalpha, Ribonucleoprotein Complex Subunit Organization