TNFRSF12A antibody (AA 28-129)
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- Target See all TNFRSF12A Antibodies
- TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
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Binding Specificity
- AA 28-129
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TNFRSF12A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWPILGGALS LTFVLGLLSG FLVWRRCRRR EKFTTPIEET GGEGCPAVAL IQ
- Cross-Reactivity
- Human
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 28-129 of human TWEAKR/Fn14/CD266 (NP_057723.1).
- Isotype
- IgG
- Top Product
- Discover our top product TNFRSF12A Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
- Alternative Name
- TNFRSF12A (TNFRSF12A Products)
- Synonyms
- CD266 antibody, FN14 antibody, TWEAKR antibody, AI255180 antibody, C87282 antibody, Fn14 antibody, HPIP antibody, TWEAK-R antibody, TweakR antibody, TNF receptor superfamily member 12A antibody, tumor necrosis factor receptor superfamily, member 12a antibody, TNFRSF12A antibody, Tnfrsf12a antibody
- Background
- Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Human and mouse TNFRSF12A share 82 % aa sequence identity. TNFRSF12A transcript was expressed at high levels in heart, placenta, and kidney, at intermediate levels in lung, skeletal muscle, and pancreas, and at low levels in brain and liver. In addition, elevated TNFRSF12A expression was found in human liver cancer cell lines and hepatocellular carcinoma specimens. TNFRSF12A is the weak inducer of apoptosis in some cell types. It promotes angiogenesis and the proliferation of endothelial cells. TNFRSF12A may modulate cellular adhesion to matrix proteins.,TNFRSF12A,CD266,FN14,TWEAKR,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Growth factor,TNF,Immunology & Inflammation,CD markers,NF-kB Signaling Pathway,Cardiovascular,Angiogenesis,TNFRSF12A
- Molecular Weight
- 10 kDa/13 kDa
- Gene ID
- 51330
- UniProt
- Q9NP84
- Pathways
- Apoptosis, Regulation of Cell Size
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