IL-10RA antibody (pSer319, pSer323)

Catalog No. ABIN616045

This Rabbit Polyclonal antibody specifically detects IL-10RA in WB. It exhibits reactivity toward Human.

Quick Overview for IL-10RA antibody (pSer319, pSer323) (ABIN616045)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-10RA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-10RA Antibody

Binding Specificity: pSer319, pSer323

Sequence: D-S(p)-G-F-G-S(p)-T

Specificity: This antibody detects endogenous level of IL-10R subunit alpha protein only when phosphorylated at serine 319 and serine 323.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of Serine 319/Serine 323 derived from Human IL-10R subunit alpha.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Alternative Name: CDw210a / IL10RA

Background: Defects in IL10RA are the cause of inflammatory bowel disease type 28 (IBD28) [MIM:613148]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous, it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers, fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.Synonyms: IL-10R-A, IL10 Receptor alpha, Interleukin-10 receptor alpha chain

Molecular Weight: 63 kDa

Gene ID: 3587

NCBI Accession: NP_001549

UniProt: Q13651

Pathways: Growth Factor Binding