GRIA4 antibody (Internal Region)

Catalog No. ABIN618029

The Goat Polyclonal anti-GRIA4 antibody has been validated for WB, ELISA and IHC. It is suitable to detect GRIA4 in samples from Human, Mouse, Rat and Cow.

Quick Overview for GRIA4 antibody (Internal Region) (ABIN618029)

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reactivity: Human, Mouse, Rat, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This GRIA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GRIA4 Antibody

Binding Specificity: Internal Region

Cross-Reactivity: Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)

Purification: affinity purified

Immunogen: Synthetic peptide: C-KKLDQREYPGSETP, from the internal region of the protein sequence according to NP_000820.3, NP_001070711.1, NP_001070712.1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for GRIA4

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Alternative Name: GLUR4C

Background: Human glutamate receptor 4 (GRIA4) is a new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. Binding studies showed that human GluR4 transfected into simian kidney cells (COS-1) exhibits high specific binding for[3H](RS)-alpha-amino- 3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA) but not [3H]kainate. Ion substitution experiments indicate that hGluR4 receptor-linked ion channels in their homomeric state are permeable to both CA2+ and Na+ ions. Immunoprecipitation studies suggest that GRIA1 exists in situ in the form of a pentamer.

NCBI Accession: NP_000820, NP_001070712, NP_001070711

Pathways: PI3K-Akt Signaling