L1CAM antibody (CF®594)

Catalog No. ABIN6184544

This anti-L1CAM antibody is a Mouse Monoclonal antibody detecting L1CAM in FACS and IF. Suitable for Human.

Quick Overview for L1CAM antibody (CF®594) (ABIN6184544)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This L1CAM antibody is conjugated to CF®594

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: UJ127

Product Details anti-L1CAM Antibody (CF®594)

Purpose: Mouse Monoclonal anti-CD171 / L1CAM (L1 Cell Adhesion Molecule) (UJ127), CF594 Conjugate

Characteristics: This antibody recognizes a cell surface protein of 220-240 kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius), 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs), and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Homogenous suspension of 16 week human fetal brain

Isotype: IgG1 kappa

Application Details

Application Notes: Flow Cytometry 0.5-1 μg/million cells/0.1 mL

• Immunofluorescence 1-2 μg/mL
• Optimal dilution for a specific application should be determined by user

Comment:

Neuroblastomas or Schwannomas

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: CD171 / L1CAM (L1 Cell Adhesion Molecule)

Background: CAML1, HSAS1, Hyd, L1 Cell Adhesion Molecule, L1-NCAM, MASA, MIC5, NCAM-L1, Nerve-growth factor-inducible large external glycoprotein, Neural cell adhesion molecule L1, NILE, S10, SPG1

Molecular Weight: 220-240 kDa

Gene ID: 3897, 52818

UniProt: P32004

Pathways: Synaptic Membrane