MAPK6 antibody (pSer189)

Catalog No. ABIN6241031

This Rabbit Polyclonal antibody specifically detects MAPK6 in IHC (p). It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for MAPK6 antibody (pSer189) (ABIN6241031)

Target: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5800

Product Details anti-MAPK6 Antibody

Binding Specificity: pSer189

Predicted Reactivity: C, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Phospho-ERK3-S189 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S189 of human ERK3.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MAPK6 antibody (ABIN6241031)

Wang, Kong, Lin, Li, Izumiya, Ding, Zhang, Hu, Yang, Gao, Lam, Li: "A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer." in: Acta pharmacologica Sinica, Vol. 38, Issue 6, pp. 931-942, (2018) (PubMed).

Perander, Al-Mahdi, Jensen, Nunn, Kildalsen, Johansen, Gabrielsen, Keyse, Seternes: "Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2." in: Scientific reports, Vol. 7, pp. 43471, (2017) (PubMed).

De la Mota-Peynado, Chernoff, Beeser: "Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity." in: The Journal of biological chemistry, Vol. 286, Issue 15, pp. 13603-11, (2011) (PubMed).

Purcell, Wilkins, York, Saba-El-Leil, Meloche, Robbins, Molkentin: "Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 35, pp. 14074-9, (2007) (PubMed).

Sakai, Yamauchi, Kawano: "[Measurement of internal voids in impression material using a digital image analyzer. Part 1. Investigation of the measurement system of a digital image analyzer]." in: Nihon Hotetsu Shika Gakkai zasshi, Vol. 32, Issue 1, pp. 28-36, (1989) (PubMed).

Target Details for MAPK6

Target: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Alternative Name: ERK3

Background: ERK3 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Molecular Weight: 82681

NCBI Accession: NP_002739

UniProt: Q16659

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C