GNMT antibody (C-Term)

Catalog No. ABIN6242958

There are 2+ publications for this product available. The Rabbit Polyclonal anti-GNMT antibody is suitable to detect GNMT in samples from Human. It has been validated for WB.

Quick Overview for GNMT antibody (C-Term) (ABIN6242958)

Target: GNMT (Glycine N-Methyltransferase (GNMT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNMT antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5760

Product Details anti-GNMT Antibody

Binding Specificity: AA 218-248, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-248 amino acids from the C-terminal region of human GNMT.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GNMT antibody (ABIN6242958)

Wagner, Choi, Panzitt, Mamrosh, Lee, Zaufel, Xiao, Wooton-Kee, Ståhlman, Newgard, Borén, Moore: "Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism." in: Hepatology (Baltimore, Md.), Vol. 63, Issue 1, pp. 95-106, (2016) (PubMed).

DiBello, Dayal, Kaveti, Zhang, Kinter, Lentz, Jacobsen: "The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 3, pp. 471-85, (2010) (PubMed).

Target Details for GNMT

Target: GNMT (Glycine N-Methyltransferase (GNMT))

Alternative Name: GNMT

Background: Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.

Molecular Weight: 32742

NCBI Accession: NP_061833

UniProt: Q14749

Pathways: Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process