CHST4 antibody (C-Term)

Catalog No. ABIN6243109

This anti-CHST4 antibody is a Rabbit Polyclonal antibody detecting CHST4 in WB. Suitable for Human.

Quick Overview for CHST4 antibody (C-Term) (ABIN6243109)

Target: CHST4 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4 (CHST4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHST4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB52322

Product Details anti-CHST4 Antibody

Binding Specificity: AA 357-390, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHST4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 357-390 amino acids from the C-terminal region of human CHST4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CHST4

Target: CHST4 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4 (CHST4))

Alternative Name: CHST4

Background: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.

Molecular Weight: 45134

UniProt: Q8NCG5