DNMT3B antibody (AA 356-390)

Catalog No. ABIN6243167

This Rabbit Polyclonal antibody specifically detects DNMT3B in WB. It exhibits reactivity toward Mouse.

Quick Overview for DNMT3B antibody (AA 356-390) (ABIN6243167)

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT3B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50993

Product Details anti-DNMT3B Antibody

Binding Specificity: AA 356-390

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Dnmt3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 356-390 amino acids from the Central region of Mouse Dnmt3b.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Alternative Name: Dnmt3b

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).

Molecular Weight: 97228

UniProt: O88509