FER antibody (AA 1-300)

Catalog No. ABIN6243360

The Mouse Monoclonal anti-FER antibody has been validated for WB and IHC (p). It is suitable to detect FER in samples from Human and Mouse. There is 1 publication available.

Quick Overview for FER antibody (AA 1-300) (ABIN6243360)

Target: FER (FER Tyrosine Kinase (FER))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FER antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1457CT181-12-17

Product Details anti-FER Antibody

Binding Specificity: AA 1-300

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This FER antibody is generated from a mouse immunized with a recombinant protein.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FER antibody (ABIN6243360)

Meng, Chen, Zhang: "Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes." in: International journal of biological sciences, Vol. 13, Issue 8, pp. 985-995, (2018) (PubMed).

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: FER

Background: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Molecular Weight: 94638

UniProt: P16591