COMMD1 antibody

Catalog No. ABIN6243631

This anti-COMMD1 antibody is a Rabbit Polyclonal antibody detecting COMMD1 in WB. Suitable for Human.

Quick Overview for COMMD1 antibody (ABIN6243631)

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMMD1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB54338

Product Details anti-COMMD1 Antibody

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COMMD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4--33 amino acids from human COMMD1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for COMMD1

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Alternative Name: COMMD1

Background: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2 (PubMed:< a href="http://www.uniprot.org/citations/21778237" target="_blank">21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:< a href="http://www.uniprot.org/citations/15799966" target="_blank">15799966, PubMed:< a href="http://www.uniprot.org/citations/17183367" target="_blank">17183367, PubMed:< a href="http://www.uniprot.org/citations/20048074" target="_blank">20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:< a href="http://www.uniprot.org/citations/23515529" target="_blank">23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:< a href="http://www.uniprot.org/citations/14645214" target="_blank">14645214, PubMed:< a href="http://www.uniprot.org/citations/20237237" target="_blank">20237237, PubMed:< a href="http://www.uniprot.org/citations/21741370" target="_blank">21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:< a href="http://www.uniprot.org/citations/21483833" target="_blank">21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:< a href="http://www.uniprot.org/citations/20595380" target="_blank">20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:< a href="http://www.uniprot.org/citations/25355947" target="_blank">25355947). Can bind one copper ion per monomer (PubMed:< a href="http://www.uniprot.org/citations/17309234" target="_blank">17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:< a href="http://www.uniprot.org/citations/18940794" target="_blank">18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:< a href="http://www.uniprot.org/citations/20458141" target="_blank">20458141).

Molecular Weight: 21178

UniProt: Q8N668

Pathways: Transition Metal Ion Homeostasis