L3MBTL1 antibody (AA 451-485)

Catalog No. ABIN6243755

This Rabbit Polyclonal antibody specifically detects L3MBTL1 in WB. It exhibits reactivity toward Mouse.

Quick Overview for L3MBTL1 antibody (AA 451-485) (ABIN6243755)

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB53645

Product Details anti-L3MBTL1 Antibody

Binding Specificity: AA 451-485

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This L3MBTL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 451-485 amino acids from the Central region of human L3MBTL1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Alternative Name: L3MBTL1

Background: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

Molecular Weight: 92297

UniProt: Q9Y468

Pathways: Chromatin Binding