TAB3 antibody (N-Term)

Catalog No. ABIN6252829

The Rabbit Polyclonal anti-TAB3 antibody has been validated for WB. It is suitable to detect TAB3 in samples from Human and Mouse.

Quick Overview for TAB3 antibody (N-Term) (ABIN6252829)

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TAB3 Antibody

Binding Specificity: N-Term

Purification: Protein A purified antibody

Immunogen: A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: Western blot: 4-8 μg/mL

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Target Details for TAB3

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Alternative Name: TAB3

Background: TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.

Gene ID: 257397

UniProt: Q8N5C8

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades