CD16 antibody

Catalog No. ABIN6253847

This anti-CD16 antibody is a Mouse Monoclonal antibody detecting CD16 in FACS and ICC. Suitable for Human.

Quick Overview for CD16 antibody (ABIN6253847)

Target: CD16

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD16 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: B-E16

Product Details anti-CD16 Antibody

Specificity: B-E16 produces mouse IgG2a immunoglobulins specific for a 50-70 kD antigen which is associated with the IgG FceRI on NK cells, neutrophils, granulocytes and monocytes [3]

Purity: PURE

Isotype: IgG2a

Application Details

Application Notes: immunohistochemistry on cytospots,  immunohistochemistry on frozen tissue

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C

Target Details for CD16

Target: CD16

Alternative Name: CD16

Background: Antigen distribution: CD16 is a low-affinity receptor for aggregated IgG (FcgRIII) [1,2]. The transmembrane form of CD16 is expressed on approximately 15% of peripheral blood lymphocytes and is present on virtually all resting NK cells. It is also found on macrophages and mast cells. It binds IgG complexed to antigens and mediates phagocytosis and antibody-dependent cellular cytotoxicity. On NK cells it mediates signal transduction while the GPI-linked form on neutrophils binds to ligands but is unable to induce any signal or functional effect [1]. Cellular Expression: NK cells, neutrophils, granulocytes, macrophages.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process