Ataxin 3 antibody (AA 120-250)

Catalog No. ABIN6254159

The Goat Polyclonal anti-Ataxin 3 antibody is suitable to detect Ataxin 3 in samples from Human, Mouse, Rat, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog, Monkey, Pig, Cat, Chicken, Donkey, Goat, Hamster and Avian. It has been validated for WB.

Quick Overview for Ataxin 3 antibody (AA 120-250) (ABIN6254159)

Target: Ataxin 3 (ATXN3)

Reactivity: Human, Mouse, Rat, Cow, Sheep, Horse, Rabbit, Guinea Pig, Dog, Monkey, Pig, Cat, Chicken, Donkey, Goat, Hamster, Avian

Host: Goat

Clonality: Polyclonal

Conjugate: This Ataxin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ataxin 3 Antibody

Binding Specificity: AA 120-250

Purpose: Anti-ATXN3

Sequence: KEHWFTVRKL GKQWFNLNSL LTGPELISDT YLALFLAQLQ QEGYSIFVVK GDLPDCEADQ LLQMIRVQQM HRPKLIGEEL AQLKEQRVHK TDLERVLEAN DGSGMLDEDE EDLQRALALS RQEIDMEDEE ADL

Specificity: Detects levels of ATXN3 protein in transfected cells with GFP-ATXN3 and endogenous levels in U118, SH-SY5Y, At-T20 and hTERT cell lysates by Western blot. This Ab is similar to AB0089.

Characteristics: Ataxin 3

Purification: Epitope affinity purified

Immunogen: Purified recombinant peptide derived from within residues 120 aa to 250 aa of human ATXN3 produced in E. coli.

Isotype: IgG

Application Details

Application Notes: WB:1:250-1:2,000

Restrictions: For Research Use only

Handling

Buffer: preservatives. Glycerol and azide FREE.

Preservative: Azide free

Handling Advice: The antibody solution should be gently mixed before use.

Storage: 4 °C,-20 °C

Storage Comment: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Target Details for Ataxin 3

Target: Ataxin 3 (ATXN3)

Alternative Name: ATXN3

Background:

Goat polyclonal antibody to ATXN3. This protein appears to be a component of the ubiquitin proteasome system and has deubiquitinase activity. It may also have roles in neuroprotection, protein homeostasis maintenance, transcriptional and cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. The protein contains Qn repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease also known as spinocerebellar ataxia-3, an autosomal dominant neurologic disorder.

AT3, ATX3, ataxin-3, ataxin 3 variant h, autosomal dominant ataxin 3, ataxin 3 variant m, ataxin 3 variant ref, JOS, josephin, Machado-Joseph, Machado-Joseph disease protein 1, MJD, MJD1, SCA3, spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, spinocerebellar ataxia type 3 protein antibody.