NOTCH2 antibody
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- Target See all NOTCH2 Antibodies
- NOTCH2 (Notch 2 (NOTCH2))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NOTCH2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Cleaved-Notch2 (Asp1733) Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Asp1733.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NOTCH2 (UniProt Q04721), corresponding to amino acid residues L1717-S1741.
- Isotype
- IgG
- Top Product
- Discover our top product NOTCH2 Primary Antibody
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anti-Notch 2 (NOTCH2) antibody
NOTCH2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Asp1733), (cleaved) antibodyNOTCH2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (C-Term) antibodyNOTCH2 Reactivity: Human, Mouse WB, ChIP-seq Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Asp1733) antibodyNOTCH2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 59-250) antibodyNOTCH2 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2251-2466) antibodyNOTCH2 Reactivity: Human WB, ELISA, IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 1501-1700) antibodyNOTCH2 Reactivity: Human, Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2242-2471) antibodyNOTCH2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734) antibodyNOTCH2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734), (Internal Region) antibodyNOTCH2 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- NOTCH2 (Notch 2 (NOTCH2))
- Alternative Name
- NOTCH2 (NOTCH2 Products)
- Background
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Description: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Gene: NOTCH2
- Molecular Weight
- 110 kDa
- Gene ID
- 4853
- UniProt
- Q04721
- Pathways
- Notch Signaling, Stem Cell Maintenance
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