GABA-RB (pSer434) antibody

Catalog No. ABIN6256337

This Rabbit Polyclonal antibody specifically detects GABA-RB in IHC, ELISA, WB, ICC and IF. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for GABA-RB (pSer434) antibody (ABIN6256337)

Target: GABA-RB

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details

Binding Specificity: pSer434

Specificity: Phospho-GABA-RB (Ser434) Antibody detects endogenous levels of GABA-RB only when phosphorylated at Serine 434

Cross-Reactivity: Human, Monkey, Mouse (Murine), Rat (Rattus)

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human GABA-RB around the phosphorylation site of Serine 434

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details

Target: GABA-RB

Background:

Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital, these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Gene: GABRB1

Molecular Weight: 55kDa

Gene ID: 2560

UniProt: P18505