GABA-RB (pSer434) antibody
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- Target
- GABA-RB
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Binding Specificity
- pSer434
- Reactivity
- Human, Mouse, Rat, Monkey
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
- Application
- Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- Phospho-GABA-RB (Ser434) Antibody detects endogenous levels of GABA-RB only when phosphorylated at Serine 434
- Cross-Reactivity
- Human, Monkey, Mouse (Murine), Rat (Rattus)
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human GABA-RB around the phosphorylation site of Serine 434
- Isotype
- IgG
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- GABA-RB
- Background
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Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital, these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Gene: GABRB1
- Molecular Weight
- 55kDa
- Gene ID
- 2560
- UniProt
- P18505
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