KDM5D antibody (C-Term)

Catalog No. ABIN6256832

This Rabbit Polyclonal antibody specifically detects KDM5D in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for KDM5D antibody (C-Term) (ABIN6256832)

Target: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-KDM5D Antibody

Binding Specificity: C-Term

Specificity: JAD1D Antibody detects endogenous levels of total JAD1D.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human JAD1D, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for KDM5D

Target: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Alternative Name: KDM5D

Background:

Description: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes, in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Gene: KDM5D

Gene ID: 8284

UniProt: Q9BY66

Pathways: Warburg Effect