BMP10 antibody (Internal Region)

Catalog No. ABIN6256960

This anti-BMP10 antibody is a Rabbit Polyclonal antibody detecting BMP10 in WB, ELISA, ICC and IF. Suitable for Human.

Quick Overview for BMP10 antibody (Internal Region) (ABIN6256960)

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-BMP10 Antibody

Binding Specificity: Internal Region

Specificity: BMP10 Antibody detects endogenous levels of total BMP10.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BMP10, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for BMP10

Target: BMP10 (Bone Morphogenetic Protein 10 (BMP10))

Alternative Name: BMP10

Background:

Description: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene: BMP10

Molecular Weight: 48 kDa

Gene ID: 27302

UniProt: O95393

Pathways: Hormone Activity, Regulation of Muscle Cell Differentiation