MAGEC2 antibody (Internal Region)

Catalog No. ABIN6257317

This anti-MAGEC2 antibody is a Rabbit Polyclonal antibody detecting MAGEC2 in ELISA, WB, IF and ICC. Suitable for Human.

Quick Overview for MAGEC2 antibody (Internal Region) (ABIN6257317)

Target: MAGEC2 (Melanoma Antigen Family C, 2 (MAGEC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGEC2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-MAGEC2 Antibody

Binding Specificity: Internal Region

Specificity: MAGEC2 Antibody detects endogenous levels of total MAGEC2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MAGEC2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MAGEC2

Target: MAGEC2 (Melanoma Antigen Family C, 2 (MAGEC2))

Alternative Name: MAGEC2

Background:

Description: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

Gene: MAGEC2

Molecular Weight: 41 kDa

Gene ID: 51438

UniProt: Q9UBF1