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CREB3L2 antibody (Internal Region)

CREB3L2 Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257984
  • Target See all CREB3L2 Antibodies
    CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))
    Binding Specificity
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 32
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 29
    • 2
    • 2
    Rabbit
    Clonality
    • 31
    • 2
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CREB3L2 antibody is un-conjugated
    Application
    • 26
    • 21
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    CREB3L2 Antibody detects endogenous levels of total CREB3L2.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CREB3L2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CREB3L2 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2 (CREB3L2))
    Alternative Name
    CREB3L2 (CREB3L2 Products)
    Synonyms
    CREB3L2 antibody, bbf2h7 antibody, BBF2H7 antibody, C530025K05Rik antibody, Ra69 antibody, SCIRR69 antibody, zgc:158603 antibody, cAMP responsive element binding protein 3 like 2 antibody, cAMP responsive element binding protein 3-like 2 antibody, cAMP responsive element binding protein 3-like 2 L homeolog antibody, CREB3L2 antibody, creb3l2 antibody, Creb3l2 antibody, creb3l2.L antibody
    Background

    Description: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).

    Gene: CREB3L2

    Molecular Weight
    58 kDa
    Gene ID
    64764
    UniProt
    Q70SY1
    Pathways
    Thyroid Hormone Synthesis
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