SLC4A8/10 antibody

Catalog No. ABIN6258561

The Rabbit Polyclonal anti-SLC4A8/10 antibody is suitable to detect SLC4A8/10 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, ICC and IF.

Quick Overview for SLC4A8/10 antibody (ABIN6258561)

Target: SLC4A8/10 (Solute Carrier Family 4, Member 8/10 (SLC4A8/10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC4A8/10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-SLC4A8/10 Antibody

Specificity: SLC4A8/10 Antibody detects endogenous levels of total SLC4A8/10

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide

Isotype: IgG

Application Details

Application Notes: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for SLC4A8/10

Target: SLC4A8/10 (Solute Carrier Family 4, Member 8/10 (SLC4A8/10))

Alternative Name: SLC4A8/10

Background:

Description: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in  pH regulation in neurons. May be involved in cell  pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.

Gene: SLC4A8

Molecular Weight: 140 kDa

Gene ID: 9498

UniProt: Q2Y0W8, Q6U841