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PARD3 antibody (C-Term)

PARD3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259144
  • Target See all PARD3 Antibodies
    PARD3 (Par-3 Partitioning Defective 3 Homolog (PARD3))
    Binding Specificity
    • 15
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 55
    • 24
    • 16
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 53
    • 3
    Rabbit
    Clonality
    • 55
    • 1
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PARD3 antibody is un-conjugated
    Application
    • 42
    • 23
    • 13
    • 13
    • 11
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    PARD3 Antibody detects endogenous levels of total PARD3.
    Predicted Reactivity
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PARD3, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PARD3 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    PARD3 (Par-3 Partitioning Defective 3 Homolog (PARD3))
    Alternative Name
    PARD3 (PARD3 Products)
    Synonyms
    ASIP antibody, Baz antibody, PAR3 antibody, PAR3alpha antibody, PARD-3 antibody, PARD3A antibody, SE2-5L16 antibody, SE2-5LT1 antibody, SE2-5T2 antibody, Par3 antibody, AA960621 antibody, AI256638 antibody, D8Ertd580e antibody, PAR-3 antibody, Pard3a antibody, asip antibody, bazooka antibody, par-3 antibody, par3 antibody, pard3 antibody, par-3 family cell polarity regulator antibody, partitioning defective 3 homolog antibody, par-3 family cell polarity regulator alpha, b antibody, par-3 family cell polarity regulator S homeolog antibody, PARD3 antibody, Pard3 antibody, LOC100551156 antibody, LOC100473914 antibody, pard3 antibody, pard3ab antibody, pard3.S antibody
    Background

    Description: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).

    Gene: PARD3

    Molecular Weight
    151 kDa
    Gene ID
    56288
    UniProt
    Q8TEW0
    Pathways
    Cell-Cell Junction Organization
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