CABP1 antibody (Internal Region)

Catalog No. ABIN6260388

The Rabbit Polyclonal anti-CABP1 antibody has been validated for WB and ELISA. It is suitable to detect CABP1 in samples from Human, Mouse and Rat.

Quick Overview for CABP1 antibody (Internal Region) (ABIN6260388)

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CABP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CABP1 Antibody

Binding Specificity: Internal Region

Specificity: CABP1 Antibody detects endogenous levels of total CABP1.

Predicted Reactivity: Pig,Bovine,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CABP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CABP1

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Alternative Name: CABP1

Background:

Description: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).

Gene: CABP1

Molecular Weight: 40 kDa

Gene ID: 9478

UniProt: Q9NZU7

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity