CBX2 antibody (Internal Region)

Catalog No. ABIN6260519

This Rabbit Polyclonal antibody specifically detects CBX2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CBX2 antibody (Internal Region) (ABIN6260519)

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CBX2 Antibody

Binding Specificity: Internal Region

Specificity: CBX2 Antibody detects endogenous levels of total CBX2.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CBX2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CBX2

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Alternative Name: CBX2

Background:

Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).

Gene: CBX2

Molecular Weight: 56 kDa

Gene ID: 84733

UniProt: Q14781