CBX2 antibody (N-Term)

Catalog No. ABIN2784551

The Rabbit Polyclonal anti-CBX2 antibody (ABIN2784551) specifically detects CBX2 in WB and IP. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig and Rabbit samples.

Quick Overview for CBX2 antibody (N-Term) (ABIN2784551)

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-CBX2 Antibody

Binding Specificity: N-Term

Purpose: CBX2 Antibody - N-terminal region

Sequence: SSSSSSSTSS SSSSDEEDDS DLDAKRGPRG RETHPVPQKK AQILVAKPEL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CBX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBX2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8097003

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBX2

Target: CBX2 (Chromobox Homolog 2 (CBX2))

Alternative Name: CBX2

Background:

Background Information: CBX2 Contains 1 A.T hook DNA-binding domain and 1 chromo domain. CBX2 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Name: Chromobox homolog 2

Alternative Symbols: M33, CDCA6, SRXY5

Protein Name: Chromobox protein homolog 2

Molecular Weight: 56kDa

Gene ID: 84733

NCBI Accession: NP_005180

UniProt: Q14781