CTNNA2 antibody (C-Term)

Catalog No. ABIN6261087

The Rabbit Polyclonal anti-CTNNA2 antibody has been validated for WB, ELISA, IF and ICC. It is suitable to detect CTNNA2 in samples from Human.

Quick Overview for CTNNA2 antibody (C-Term) (ABIN6261087)

Target: CTNNA2 (Catenin (Cadherin-Associated Protein), alpha 2 (CTNNA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNNA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-CTNNA2 Antibody

Binding Specificity: C-Term

Specificity: CTNNA1/CTNNA2 Antibody detects endogenous levels of total CTNNA1/CTNNA2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CTNNA1/CTNNA2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CTNNA2

Target: CTNNA2 (Catenin (Cadherin-Associated Protein), alpha 2 (CTNNA2))

Alternative Name: CTNNA1,CTNNA2

Background:

Description: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Gene: CTNNA1

Molecular Weight: 100kDa

Gene ID: 1495, 1496

UniProt: P35221, P26232

Pathways: Regulation of Muscle Cell Differentiation